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Integrated network analysis, proteomics, and experimental validation reveal the mechanisms underlying the renoprotective effects of salvianolic acid A against diabetic nephropathy
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DOI：10.1016/j.jep.2026.122209.png)
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Abstract
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Salvianolic acid A (SAA), a major bioactive constituent of Salvia miltiorrhiza, has attracted considerable attention because of its diverse pharmacological activities in metabolic and vascular disorders. Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and remains a leading cause of end-stage renal disease worldwide. Although increasing evidence has demonstrated the renoprotective effects of SAA, the precise molecular mechanisms underlying its therapeutic actions in DN remain incompletely understood.
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