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Integrating traditional Chinese medicine and modern technology: A new approach to understanding Changmaxifeng granules for tic disorders
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DOI：10.5498/wjp.v16.i3.114342.png)
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Abstract
En 中文
Tic disorders (TDs) are neuropsychiatric conditions characterized by involuntary motor and vocal tics, predominantly affecting children and adolescents. Conventional treatments, primarily psychotropic agents, are often associated with significant side effects and limited long-term efficacy. Changmaxifeng granules (CG), a traditional Chinese medicine formulation, have demonstrated promising clinical results in managing TDs; however, their pharmacodynamic basis and mechanisms of action remain poorly understood. This editorial highlights a study by Xie et al that integrates serum pharmacochemistry, network pharmacology, and molecular docking to systematically elucidate the multi-component, multi-target therapeutic profile of CG. The study identified 187 chemical constituents in vitro and 75 blood-absorbed components (49 prototypes and 26 metabolites) in vivo, with paeoniflorin, gastrodin, tenuifolin, and gallic acid emerging as key bioactive compounds. Network analysis identified critical targets - including tumor necrosis factor, interleukin-6, Fos proto-oncogene, vascular endothelial growth factor A, and estrogen receptor 1 - and highlighted the involvement of inflammatory and neuroactive pathways in TD pathology. Molecular docking confirmed strong binding affinities between core compounds and these targets, supporting CG's potential as a safer and effective alternative therapy. While these computational findings are compelling, they require validation in physiological systems. These findings bridge traditional medicine and modern pharmacology, providing a good foundation for future clinical validation and new drug development. Future research should prioritize in vivo functional studies, quantitative pharmacokinetic profiling, and larger-scale clinical trials utilizing precision medicine frameworks that integrate artificial intelligence-driven syndrome stratification, metabolomic biomarkers, and real-time monitoring to fully realize CG's potential for personalized herbotherapy in TD management.
Keywords:
Tic disorders
Changmaxifeng granules
Network pharmacology
Molecular docking
Precision medicine
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3.4
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269
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0
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Cited Papers