Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC

Yanmei Yang

doi:10.1016/j.celrep.2026.117797

Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC

2026-08-08

0

OA

AI

Y

Yanmei Yang

P

Peixian Li

L

Liangbo Zhao

L

Lingwei Zhang

H

Hong Chen

H

Hao Xing

P

Pingping Zhu

J

Jing An

L

Luyun He

S

Shuiling Jin

N

Nian Liu

S

Shuaixi Yang *

X

Xiao Sun *

B

Benyu Liu *

DOI：10.1016/j.celrep.2026.117797

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Abstract

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• Stem-like HCC cells exhibit extensive 3D genome reprogramming • Stemness-associated chromatin rewiring drives differential TP53RK and SYBU expression • TP53RK enhances mitophagy-dependent stemness, whereas SYBU restrains MAPK signaling • Co-targeting TP53RK and PD-1 improves anti-tumor immune responses

Keywords:

epigenome

HCC

stemness

TP53RK

tumor immunity

CP: cancer

CP: stem cell research

Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC

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