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Integrative Chinese Herbal Medicine as Adjuvant Management for Triple-Negative Breast Cancer: A Multi-Institutional Real-World Study With Mechanism Exploration
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DOI：10.1177/15347354261451843.png)
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Abstract
En 中文
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>Triple-negative breast cancer (TNBC) is a major cause of mortality worldwide. Chinese herbal medicine (CHM) is often used as adjunctive therapy, but its long-term impact on TNBC remains unclear.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Materials and methods:</jats:title>
<jats:p>This study analyzed a multi-institutional cohort from the Chang Gung Research Database, investigating long-term outcomes of integrative CHM use in TNBC patients newly diagnosed between January 1, 2011, and December 31, 2021. Patients were followed for up to 10 years or until death. Overall survival rate (OS) and disease-specific survival rates were assessed using Kaplan–Meier estimation with overlap weighting and landmark analysis to reduce bias. Core CHMs were identified through network pharmacology analysis on prescriptions made for TNBC patients.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>
The analysis included 2174 TNBC patients, with 464 using CHM. CHM use was associated with a significantly higher 10-year OS compared to non-users (77.7% vs 70.2%,
<jats:italic toggle="yes">P</jats:italic>
= .007). In stages 1 to 3, the OS among CHM users was 6.6% higher (80.7% vs 74.1%,
<jats:italic toggle="yes">P</jats:italic>
= .018). After adjusting for demographic factors, CHM use reduced the risk of all-cause mortality (adjusted hazard ratio [aHR]: 0.71,
<jats:italic toggle="yes">P</jats:italic>
= .044). Lower disease-specific survival rates were observed among CHM users. Core CHMs, such as
<jats:italic toggle="yes">Hedyotis diffusa Willd.</jats:italic>
, may have potential anti-cancer effects, while combinations like Jia-Wei-Xiao-Yao-San,
<jats:italic toggle="yes">Scutellaria barbata</jats:italic>
D. Don. and Suan-Zao-Ren-Tang may have a complementary role to standard treatments for TNBC.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion:</jats:title>
<jats:p>Use of CHM may improve 10-year OS in TNBC patients, and core CHMs provided crucial references for further studies.</jats:p>
</jats:sec>
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