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Integrative Multiomics Analysis Identifies DKK3 as a Germline Susceptibility-Related Regulator of Risperidone Response and Metabolic Risk in Schizophrenia

delete2026-06-17
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X
Xiaoyun Zhang
J
Jingjing Li
Y
Yao Sun
G
Gangrui Hei
X
Xueqin Song *
DOI:10.1155/humu/8434158delete
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Abstract

Abstract

En 中文
Risperidone is a widely used second-generation antipsychotic for schizophrenia, known for its clinical efficacy but also for long-term metabolic side effects, including weight gain and glucose–lipid dysregulation. Although its therapeutic effects have been well characterized, the molecular basis linking its benefits and adverse metabolic outcomes remains poorly understood.
Keywords:
DKK3
germline mutation
metabolic dysregulation
risperidone
schizophrenia
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Human Mutation cover
Human Mutation
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the first affiliated hospital of zhengzhou university
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