Interaction of tryptophan-based peptides with mixed lipid bilayers modulates bilayers’ hydrophobic region in an anionic lipid-dependent manner

Lea Pašalić

doi:10.1016/j.chemphyslip.2026.105591

Interaction of tryptophan-based peptides with mixed lipid bilayers modulates bilayers’ hydrophobic region in an anionic lipid-dependent manner

2026-05-29

0

PRE

AI

L

Lea Pašalić

P

Petra Maleš

B

Barbara Pem

A

Andreja Jakas

J

Jakob Wallner

T

Tea Kuvek

N

Nadine Grundschober

E

Edgar Galicia-Andrés

D

Dražen Petrov

D

Danijela Bakarić *

DOI：10.1016/j.chemphyslip.2026.105591

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Abstract

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• Mixed zwitterionic-anionic lipid bilayers in the presence of peptides were studied • DPPC+DPPS bilayers are more sensitive to peptide adsorption than DPPC+DPPG • Arginine-based peptide penetrates deeper than its lysine analogue • Surface interaction affects the packing pattern across the non-polar bilayer part

Keywords:

peptide-lipid interaction

zwitterionic-anionic lipid bilayers

hydrophobic region

anionic lipid dependence

peptide penetration

Interaction of tryptophan-based peptides with mixed lipid bilayers modulates bilayers’ hydrophobic region in an anionic lipid-dependent manner

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