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Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter
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DOI：10.1364/OPTICA.472471.png)
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Abstract
En 中文
Diffuse optics (DO) is a light-based technique used to study the human brain, but it suffers from low brain specificity. Interferometric diffuse optics (iDO) promises to improve the quantitative accuracy and depth specificity of DO, and particularly, coherent light fluctuations (CLFs) arising from blood flow. iDO techniques have alternatively achieved either time-of-flight (TOF) discrimination or highly parallel detection, but not both at once. Here, we break this bar-rier with a single iDO instrument. Specifically, we show that rapid tuning of a temporally coherent laser during the sensor integration time increases the effective linewidth seen by a highly parallel interferometer. Using this concept to create a continuously variable and user-specified TOF filter, we demonstrate a solution to the canonical problem of DO, measuring optical properties. Then, with a deep TOF filter, we reduce scalp sensitivity of CLFs by 2.7 times at 1 cm source-collector separation. With this unique combination of desirable features, i.e., TOF-discrimination, spatial localization, and highly parallel CLF detection, we perform multiparametric imaging of light intensities and CLFs via the human forehead. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
Keywords:
NEAR-INFRARED SPECTROSCOPY
CEREBRAL-BLOOD-FLOW
CONTRAST OPTICAL SPECTROSCOPY
NONINVASIVE MEASUREMENT
INTRACRANIAL-PRESSURE
ABSORPTION
SPECKLE
REFLECTANCE
BRAIN
SCATTERING
Journal
IF:
8.5
Papers:
2.4K
Citations:
2.1W
