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Intermetallic nanoassemblies potentiate systemic STING activation

delete2026-05-07
delete0
PRE
AI
X
Xingwu Zhou
X
Xiang Ling
X
Xiaoqi Sun
Z
Ziye Wan
T
Tobias Dwyer
T
Timothy C. Moore
Q
Quguang Li
H
Hannah E. Dobson
Q
Qi Wu
X
Xiangbo Kong
F
Fang Xie
X
Xinran An
J
Jingyao Gan
K
Kaikai Wang
Y
Young Seok Cho
W
Wang Gong
K
Katherine Dong
J
Jie Zhang
M
Mariko Takahashi
C
Cheng Xu
S
Swetha Kodamasimham
J
Jie Xu
V
Vilma Yuzbasiyan-Gurkan
S
Steven B. Chinn
A
Anna Schwendeman
S
Sharon C. Glotzer
Y
Yu L. Lei
J
James J. Moon *
DOI：10.1126/science.adx1893delete
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Abstract

Abstract

En 中文
Molecules that activate innate immune signaling through the stimulator of interferon genes (STING) pathway are of interest for cancer therapies. However, the use of agonists developed for this purpose has been hampered because they generally require high doses and can be toxic. Zhou et al. generated an intermetallic nanoparticle called CRYSTAL that self-assembles when manganese ions intercalate with cyclic dinucleotides (see the Perspective by Liao and Irvine). CRYSTAL was able to activate STING, could control tumors at low doses in mice and rabbits, and had a promisingly low toxicity profile. Rather than acting on cancer cells, CRYSTAL activated STING in myeloid cells preferentially, promoting antitumor T cell responses. —Sarah H. Ross
Keywords:
STING pathway
cancer therapy
intermetallic nanoparticles
innate immune signaling
myeloid cells

Journal

Science cover
Science
IF:
45.8
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1.4W
Citations:
78.6W

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T
The University of Texas MD Anderson Cancer Center
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3.5K
Papers: 771
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M
michigan state university
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U
university of michigan
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