Intermittent fasting ameliorates Sjögren's syndrome-related dry eye through a preponderant bile acid-Akkermansia homeostasis establishment

2026-06-27

PRE

Bowen Wang

Wenrui Deng

Kai Liao

Ruiqi Bai

Lihong Liang

Xue Yang

Hao Zeng

Runze Zhang

Shiyou Zhou *

Xiaoran Wang *

Jin Yuan *

DOI：10.1016/j.jaut.2026.103590

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• IF improves tear secretion and corneal integrity in Sjögren-related dry eye. • Gut microbiota and metabolome are coordinately reshaped following IF. • Akkermansia and ursodeoxycholic acid supplementation mimics IF benefits. • IF reduces lacrimal gland Th17 infiltration and induces protective CD8+ T cells.

Intermittent fasting ameliorates Sjögren's syndrome-related dry eye through a preponderant bile acid-Akkermansia homeostasis establishment

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