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Interpretable deep learning framework for secure clinical data analytics
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DOI：10.1038/s41598-026-62055-8.png)
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Abstract
En 中文
The growing use of artificial intelligence in the healthcare sector has facilitated the emergence of sophisticated clinical data analytics, but the most critical issues pertain to data privacy, model interpretability, and model trustworthiness. These problems still pose a challenge to its real-world application. This study proposes an interpretation of a deep learning framework for secure clinical data analytics. This proposes a privacy-preserving distributed learning framework in combination with a naturally interpretable model structure. The suggested framework enables parallel training across several healthcare facilities without compromising raw patient information, thereby keeping the data confidential without adversely affecting the analysis. An idea-driven deep learning framework is also presented to produce clinically significant intermediate representations that enable clear, interpretable predictions. Moreover, a new explanation stability mechanism is established to maintain the consistency and reliability of model explanations in distributed environments. To promote clinical safety, the decision module includes uncertainty to enable the system to detect predictions with low confidence and defer them to experts. Massive tests using actual clinical data on patient conditions can be conducted to demonstrate that the framework presented is much more successful than other methods with respect to predictiveness, interpretability, explanation stability, fairness, and calibration. Furthermore, the framework demonstrates that privacy preservation, interpretability, explanation reliability, and clinical usability can be jointly optimized within a unified learning architecture. The findings indicate the effectiveness of the suggested strategy in providing secure, transparent, and reliable clinical decision support, rendering it an appropriate strategy to implement in contemporary healthcare systems.
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