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Intervening in PIDD1 to Decrease Treg Cell Recruitment Boosts the Effectiveness of Radiofrequency Ablation Combined with anti-PD-1 Therapy in HCC
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DOI：10.1016/j.jcmgh.2026.101844.png)
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Abstract
En 中文
The efficacy of radiofrequency ablation (RFA) is constrained by incomplete tumor ablation, particularly in cases of excessive tumor volume, leading to elevated recurrence rates. Elucidating the genetic and microenvironmental alterations following incomplete ablation is essential for improving therapeutic outcomes. We aimed to identify the tumor-intrinsic molecular link between residual tumor cells and the immunosuppressive microenvironment that drives recurrence after RFA.
Keywords:
Radiofrequency ablation
Tumor recurrence
PIDD1
Treg cells
Hepatocellular carcinoma
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