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Intestinal epithelial SETD2 maintains gut microbial homeostasis to attenuate colitis
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DOI：10.1002/ctm2.70754.png)
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Abstract
En 中文
Disruption of host–microbiota homeostasis is a fundamental hallmark of inflammatory bowel disease (IBD) pathogenesis. Host epigenetic modifications and corresponding alterations in gene expression levels can impact the composition of gut microbes. SET domain containing 2 (SETD2) is a critical epigenetic regulator with established tumor-suppressive roles, but its function in intestinal microbial ecology and colitis progression remains unexplored. We aimed to investigate the specific role of SETD2 in maintaining gut microbial homeostasis and modulating colitis progression.
Keywords:
AMPs
epigenetics
gut microbes
IBD
SETD2
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