Ionic liquid-mediated ethosome for transdermal delivery of insulin

doi:10.1039/d3cc06130b

Ionic liquid-mediated ethosome for transdermal delivery of insulin

2024-01-01

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OA

AI

Muhammad Moniruzzaman

DOI：10.1039/d3cc06130b

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Abstract

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Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability. Ethosome formulations mediated by ionic liquid were reported with high insulin encapsulation efficiency and increased skin permeation ability.

Keywords:

DRUG-DELIVERY

ETHANOL

Ionic liquid-mediated ethosome for transdermal delivery of insulin

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