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Ionic Polypeptide Polymers with Unusual β-Sheet Stability
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DOI：10.1021/acs.biomac.8b01084.png)
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Abstract
En 中文
Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL(-1)) beta-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(gamma-propargyl-L-glutamate) backbone. This synthetic methodology has been applied to the synthesis of thymidine-based nucleopolypeptides presenting stable beta-sheet conformation in aqueous solutions with pH values comprised between 4 and 8. These polymeric analogues of nucleoproteins exhibited selective interaction with simple DNA sequences displaying adenine.
Keywords:
CARBOXYMETHYL-L-CYSTEINE
HELIX-COIL TRANSITION
ANTIMICROBIAL POLYPEPTIDES
N-CARBOXYANHYDRIDES
AQUEOUS-SOLUTIONS
GENE DELIVERY
L-LYSINE
CONFORMATION
POLYMERIZATION
PROTEIN
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