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Iron accumulation drives radiation-induced proctopathy via VDR/YAP signaling
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DOI：10.1016/j.freeradbiomed.2026.08.001.png)
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Abstract
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• Radiation-induced rectal fibrosis is characterized by ferritin-mediated iron accumulation and VDR downregulation. • Iron accumulation promotes rectal fibroblast activation by suppressing VDR expression. • VDR activation inhibits YAP nuclear translocation and reverses iron-induced fibroblast activation. • Iron chelation with deferoxamine alleviates rectal fibrosis via restoring VDR and inhibiting YAP. • Targeting the iron-VDR-YAP axis represents a novel therapeutic strategy for radiation proctopathy.
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