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Iron-Catalyzed Reaction With Carboxylic Acids and Isocyanides to Access N-Formylamides
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DOI：10.1002/adsc.70528.png)
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Abstract
En 中文
Iron-catalyzed reactions of carboxylic acids with sterically hindered isocyanides enable access to N-formylamides with 100% atom economy. The substrate scope can be extended to aliphatic, aromatic, and α,β-unsaturated carboxylic acids. Furthermore, the protocol can be smoothly applied in the late-stage N-formylation of acid-containing drugs, double reaction, and N-formylation of alkynyl acids. A library of 41 N-formylamides has been constructed, and compound 4i was identified as a promising antioxidant.
Keywords:
carboxylic acids
iron-catalyzed
isocyanides
N-formylation
Journal
A
IF:
4
Papers:
424
Citations:
0