.png){kind=icon}
.png){kind=icon}
Return
Is there a link between the abundance of nitrate-reducing bacteria and arterial hypertension? A systematic review
.png){kind=icon}
PRE
AI
E
L
N
C
R
DOI：10.1016/j.niox.2025.04.001.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Context: Nitric oxide is a vasodilator molecule that acts on blood pressure (BP) control, and its production can occur through the reduction of nitrates by oral or intestinal nitrate-reducing bacteria. However, the relationship between nitrate-reducing bacteria and arterial hypertension (HTN) remains under debate. Objective: Systematically review if there is an association between the abundance of oral and intestinal nitrate-reducing bacteria and the occurrence of HTN in humans. Databases and eligibility criteria: MEDLINE, Scopus, Cochrane Library, EMBASE, LILACS, Web of Science, Livivo, ProQuest Dissertations, and Google Scholar were searched for eligible articles until February 10th, 2024. Studies were included if they: (1) were observational studies or clinical trials; (2) included adults (>18 years old) with HTN (systolic BP > 130 mmHg and/or diastolic BP > 80 mmHg and/or use of BP lowering medication); (3) compared (or not) to no-HTN adults; and (4) used next-generation sequencing microbiome analysis to identify bacterial taxa in the oral and/or gut nitrate-reducing bacteria. Results: The search identified 9365 articles, and 28 were included in the study after applying the inclusion and exclusion criteria; 23 articles assessed the gut microbiota, 4 assessed the oral microbiota, and 1 assessed both. Depletion of nitrate-reducing bacteria was not consistently shown in the studies. The included studies reported reduction, increase, and no change in the nitrate-reducing bacteria genera or species in oral or gut microbiota. Conclusion: We found no association between the abundance of oral and gut nitrate-reducing bacteria and the occurrence of HTN in humans. Registration: PROSPERO identification number CRD42022315891.
Keywords:
Nitric oxide
Oral microbiota
Gut microbiota
Cardiovascular diseases
Dysbiosis
Journal
N
IF:
3.2
Papers:
3.9K
Citations:
4.5K
Organization
Cited Papers