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Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?
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DOI：10.1002/pd.70192.png)
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Abstract
En 中文
Prenatal sequencing of fetuses with abnormalities detected on imaging is expanding globally. Debate continues over whether variants of uncertain significance (VUS) should be reported prenatally, with some recent national position statements opposing this. In England, VUS that fit the fetal phenotype and require little further evidence for upgrade are discussed at multidisciplinary team (MDT) meetings to determine whether to report. We review the VUS reported by one English laboratory that provides prenatal sequencing to half of England.
Keywords:
multidisciplinary team
prenatal
sequencing
variants of uncertain clinical significance
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