1
Return

Itaconate as a paracrine brake on thermogenesis

delete2026-07-14
delete0
PRE
AI
L
Leilei Chen *
D
Dan Ye *
DOI：10.1038/s42255-026-01573-1delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Thermogenesis must be precisely controlled to avoid wasting energy. In this issue of Nature Metabolism, Tang et al. reveal that macrophage-derived itaconate acts as a paracrine metabolic brake that blocks MCT1-dependent succinate uptake and restrains brown adipose tissue thermogenesis.

Journal

Nature Metabolism cover
Nature Metabolism
IF:
20.8
Papers:
1.6K
Citations:
1.4W

Organization

F
fudan university
Scholars:
11.3W
Papers: 7.6W
Citations: 121
Cited Papers

Cited Papers

Citing Papers

Citing Papers