.png){kind=icon}
.png){kind=icon}
Return
Juvenile Parkinson's disease: Symptom burden and treatment challenges
.png){kind=icon}
PRE
AI
L
C
A
R
L
E
J
K
R
DOI：10.1177/1877718x261473047.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
<jats:p>
Juvenile Parkinson's disease (JPD) is a rare condition characterized by the onset of parkinsonian motor symptoms before the age of 21. Sixteen patients with JPD who presented to the Mayo Clinic between 1990-2020 were included. The median age of symptoms onset was 18.5 years, and six cases had pathogenic
<jats:italic toggle="yes">PRKN</jats:italic>
mutations. Resting tremor was the most frequent initial symptom (81.3%), and non-motor symptoms were notably common, including mild cognitive impairment (56.3%), anxiety (62.5%), and depression (56.3%). Levodopa responsiveness was suboptimal in 9 patients and 14 exhibited motor fluctuations. JPD demonstrates distinct clinical characteristics compared with early-onset and late-onset PD.
</jats:p>
Journal
J
IF:
5
Papers:
1.7K
Citations:
6.5K
Organization
Cited Papers