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Kalman Inversion Stress Microscopy
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DOI：10.1016/j.bpj.2018.09.013.png)
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Abstract
En 中文
Although mechanical cues are crucial to tissue morphogenesis and development, the tissue mechanical stress field remains poorly characterized. Given traction force time-lapse movies, as obtained by traction force microscopy of in vitro cellular sheets, we show that the tissue stress field can be estimated by Kalman filtering. After validation using numerical data, we apply Kalman inversion stress microscopy to experimental data. We combine the inferred stress field with velocity and cell-shape measurements to quantify the rheology of epithelial cell monolayers in physiological conditions, found to be close to that of an elastic and active material.
Keywords:
TRACTION FORCE MICROSCOPY
EFFECTIVE VISCOSITY
CELL
MECHANOTRANSDUCTION
EPITHELIA
INFERENCE
DYNAMICS
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