Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation

Chenxi Li

doi:10.1016/j.intimp.2026.117034

Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation

2026-06-19

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AI

C

Chenxi Li

Y

Yunyao Bo

Z

Zehui Zhou

L

Li Sun

R

Ruitong Dong

Y

Yuan Yan *

DOI：10.1016/j.intimp.2026.117034

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• Keratinocyte-derived exosomes mediate TGF-β1-induced activation of human dermal fibroblasts. • TGF-β1 promotes the packaging of LINC01605 into keratinocyte-secreted exosomes. • Exosomal LINC01605 enhances fibrotic phenotypes in fibroblasts by acting as a ceRNA for miR-370-3p to upregulate TGFBR2. • LINC01605 establishes an amplification mechanism to amplify and sustain the pro-fibrotic TGF-β1/Smad signaling pathway. • Blocking exosome secretion with GW4869 alleviates skin fibrosis in a mouse model.

Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation

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