Kinetic modelling and evaluation of the TrkA/B/C radioligand [18F]TRACK in the pig brain

Cassis Varlow

doi:10.1016/j.nucmedbio.2025.109600

Kinetic modelling and evaluation of the TrkA/B/C radioligand [18F]TRACK in the pig brain

2026-01-01

0

PRE

AI

C

Cassis Varlow

C

Clara Aabye Madsen

C

Carolin Jaworski

G

Gjertrud Louise Laurell

V

Vladimir Shulganov

J

Jane Skjøth-Rasmussen

A

Arafat Nasser

R

Ralf Schirrmacher

G

Gitte M. Knudsen *

DOI：10.1016/j.nucmedbio.2025.109600

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Tropomyosin receptor kinase B (TrkB) is a critical mediator of neuronal growth, survival, and synaptic plasticity, which is activated by the endogenous ligand, brain-derived neurotrophic factor (BDNF). TrkB has been implicated in a wide range of neurological conditions, including neurodegenerative, psychiatric, and proliferative disorders. Non-invasive imaging of TrkB using positron emission tomography (PET) has been pursued to enhance understanding of its role in disease and support therapeutic development. Here, we investigated the in vitro and in vivo properties of [18F]TRACK, a fluorine-18 labeled radioligand for TrkB, in pig brain and human glioblastoma tissue.

Kinetic modelling and evaluation of the TrkA/B/C radioligand [18F]TRACK in the pig brain

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