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L-cysteine selenium nanoparticles induce apoptosis in ovarian cancer cells by activating the FOXO3a/GADD45A pathway
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DOI：10.1016/j.bioadv.2026.215099.png)
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Abstract
En 中文
• L-SeNPs were successfully synthesized and characterized. • L-SeNPs markedly suppressed ovarian cancer cell growth. • L-SeNPs induced ROS accumulation, DNA damage and apoptosis. • L-SeNPs promoted FOXO3a nuclear translocation and upregulated GADD45A expression. • FOXO3a-GADD45A signaling mediated the antitumor activity of L-SeNPs.
Keywords:
Ovarian cancer
L-cysteine selenium nanoparticles
Apoptosis
FOXO3a/GADD45A pathway
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1.9K
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