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Label-Free Detection of a Neurotransmitter Using an Aptamer-Functionalized Amorphous IGZO Transistor
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DOI：10.1002/admi.70552.png)
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Abstract
En 中文
An indium–gallium–zinc (IGZO) thin-film field-effect transistor (FET) biosensor functionalized with a serotonin-specific DNA aptamer is reported for label-free serotonin detection in aqueous environments. The device operates under liquid-gated conditions and functions as an ion-sensitive FET, enabling pH monitoring across a broad physiological range (pH 4−10). Persistent challenges in aptamer-based FET sensing—such as signal drift, interference from structurally similar molecules, and reliable integration of biomolecular layers with metal-oxide semiconductors—are discussed in the context of IGZO-based sensing platforms. The resulting devices exhibit reproducible electrical responses, with detectable serotonin response from 10 fm to 10 µm and stable short-term operation in buffered environments. This study demonstrates a straightforward approach for combining IGZO thin-film transistors with aptamer-based molecular recognition toward practical detection of small neurotransmitters.
Keywords:
aptamer
biosensor
field-effect transistor
functionalization
indium–gallium–zinc oxide
neurotransmitter
serotonin
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