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Lactate facilitates largemouth bass virus replication by promoting cholesterol biosynthesis
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DOI：10.1016/j.fsi.2026.111615.png)
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Abstract
En 中文
• LMBV infection enhanced aerobic glycolysis in vitro and in vivo. • Glucose and lactate were essential for efficient LMBV replication. • Lactate promoted LMBV replication by boosting cholesterol biosynthesis. • This study revealed a novel lactate-cholesterol-IFN axis in iridovirus pathogenesis.
Keywords:
Lactate
Largemouth bass virus (LMBV)
Cholesterol
Anti-viral
IFN response
Journal
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367
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