.png){kind=icon}
.png){kind=icon}
Return
Large Artery occlusion Treated in Extended Time with Mechanical Thrombectomy (LATE-MT): Protocol for a multicenter randomized clinical trial
.png){kind=icon}
PRE
AI
H
P
Y
X
Y
L
P
L
C
J
DOI：10.1177/17474930261458848.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>High-quality randomized controlled trials (RCTs) have extended the endovascular therapy (EVT) time window to 24 h post-stroke onset in selected patients with acute ischemic stroke (AIS). Recent retrospective studies indicate that EVT performed beyond 24 h may still improve clinical outcomes. However, the specific benefit–risk profile in this ultra-late window remains unclear.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Aim:</jats:title>
<jats:p>The trial is designed to address this evidence gap and determine the benefit–risk balance of EVT in the ultra-late window.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods and design:</jats:title>
<jats:p>The Large Artery occlusion Treated in Extended Time with Mechanical Thrombectomy (LATE-MT) is an investigator-initiated, multicenter, prospective, randomized, open, blinded-endpoint assessment (PROBE) clinical trial. The trial adopted an adaptive group-sequential design, recruiting 336 AIS patients with large-vessel occlusion within 24–72 h of the last known well across 35 stroke centers in China. Eligible subjects who meet both clinical and imaging selection criteria are randomized 1:1 to EVT or medical management.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Outcomes:</jats:title>
<jats:p>The primary outcome is an ordinal shift analysis of scores on the modified Rankin scale (mRS) at 90 days. Key secondary outcomes include neurological function at 24 h and 7 days, death/major disability, and utility-weighted mRS (UW-mRS) at 90 days. Safety outcomes include any intracranial hemorrhage (ICH), symptomatic ICH, serious adverse event, and all procedural complications.</jats:p>
</jats:sec>
Journal
IF:
8.7
Papers:
3.0K
Citations:
8.4K
Organization
Cited Papers