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Left Atrial Appendage Occlusion Using a Novel System
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DOI：10.1016/j.jcin.2025.10.002.png)
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Abstract
En 中文
Atrial fibrillation is a major stroke risk, with >90% of thrombi originating from the left atrial appendage (LAA). Oral anticoagulation is effective, but many patients cannot use it long term. Current percutaneous LAA occlusion devices reduce stroke risk but are limited by device-related thrombus (DRT) and peridevice leak.
Keywords:
atrial fibrillation
left atrial appendage closure
preclinical model
stroke prevention
AF
atrial fibrillation
CT
computed tomography
DRT
device-related thrombus
FIH
first-in-human
LAA
left atrial appendage
OAC
oral anticoagulation
PET
polyethylene terephthalate
TEE
transesophageal echocardiography
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