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Lesion-centric reprogramming: hydrogel-enabled photothermal reset of endometriosis pain
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DOI：10.1016/j.intimp.2026.116882.png)
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Abstract
En 中文
• Endometriosis-associated pelvic pain is sustained by a lesion-centered neuroinflammatory microenvironment, explaining the limited durability of systemic hormonal and surgical therapies. • Injectable and in situ–forming hydrogels enable precise, lesion-confined intervention with spatiotemporal control over drug delivery and tissue interaction. • Photothermal activation allows externally regulated, localized thermal modulation of ectopic endometrial tissue, decoupling pain control from systemic endocrine suppression. • Integration of photothermal agents within hydrogel matrices enables coordinated control of tissue ablation, intralesional drug release, and local immune signaling. • Hydrogel-enabled photothermal strategies establish a precision, non-hormonal framework for targeting pathological pain microenvironments in endometriosis.
Keywords:
Endometriosis
Hydrogel
Photothermal therapy
Pelvic pain
Neuroinflammation
Journal
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4.7
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Citations:
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