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Lessons Learned and Challenges Ahead in the Translation of Implantable Microscale Sensors and Actuators
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DOI：10.1146/annurev-bioeng-110122-121128.png)
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Abstract
En 中文
Microscale sensors and actuators have been widely explored by the scientific community to augment the functionality of conventional medical implants. However, despite the many innovative concepts proposed, a negligible fraction has successfully made the leap from concept to clinical translation. This shortfall is primarily due to the considerable disparity between academic research prototypes and market-ready products. As such, it is critically important to examine the lessons learned in successful commercialization efforts to inform early-stage translational research efforts. Here, we review the regulatory prerequisites for market approval and provide a comprehensive analysis of commercially available microimplants from a device design perspective. Our objective is to illuminate both the technological advances underlying successfully commercialized devices and the key takeaways from the commercialization process, thereby facilitating a smoother pathway from academic research to clinical impact.
Keywords:
translational research
implantable microdevice
biosensor
microcatheter
microstent
drug delivery system
neural interface
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482
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5.6K
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