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LHCGR phamacodynamic effects during follicular maturation

delete2026-08-13
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OA
AI
C
CP Carmela Perri
L
LC Livio Casarini *
C
CL Clara Lazzaretti
DOI：10.3389/fendo.2026.1917693delete
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Abstract

Abstract

En 中文
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are glycoprotein hormones that regulate human reproduction. Although they bind the same G protein-coupled membrane receptor (LHCGR) and have high percentage of structural identity; recent advances demonstrate that they mediate different signaling pattern according to their separate physiological roles. This review explores the role of LHCGR in determining the evolutionary; genetic; and physiological differences between LH and hCG. Some of these differences were revealed by mutations of the receptors; allowing the identification of LH- and hCG-specific functions in women and men. This knowledge is useful to optimize the use of molecules in clinical practice; aiming toward personalized therapies.
Keywords:
LH
gametogenesis
gonadotropins
hCG
LHCGR

Journal

Frontiers in Endocrinology cover
Frontiers in Endocrinology
IF:
4.6
Papers:
1.9W
Citations:
6.4W

Organization

U
unit of endocrinology
Scholars:
10
Papers: 5
Citations: 0
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