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Light-Driven Cell Micromotors for T Cell Activation
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DOI：10.1021/acsphotonics.6c00546.png)
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Abstract
En 中文
Precise and local activation of T cells is essential for advancing studies of immune responses and immunotherapy. Conventional schemes, relying on biochemical or physical strategies, often suffer from limited controllability or poor biocompatibility and biosafety. Here, we select natural endogenous T cells directly as the material of micromotors (without introducing any exogenous chemical or structural components) and propose scanning optical tweezer-based light-driven cell micromotors to achieve precise and local activation of a single or multiple target T cells. By navigation of the cell micromotors along programmable trajectories, two mechanical activation schemes are designed. One is direct activation from direct mechanical collision of cell micromotors, and the other is indirect activation through the hydrodynamic shear stress generated by the microvortex. Experiments and theoretical simulations jointly indicate that the T cell activation degree can be precisely controlled by adjusting the laser scanning frequency or the scanning radius. This proposed strategy has high biosafety and flexibility, precise controllability, and excellent biocompatibility, offering a versatile mechanism for cell activation in sustainable microrobotics and biomedical applications.
Keywords:
Collisions
Fluid dynamics
Lasers
Power
Stress
T cell activation
light-driven cell micromotors
optical tweezers
mechanical activation
hydrodynamic shear