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Light-emitting diode-derived blue light overexposure accelerates corneal endothelial cell aging by inducing abnormal ROS accumulation
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DOI：10.1016/j.jphotobiol.2025.113252.png)
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Abstract
En 中文
• LED blue light directly damages corneal endothelial cells (CECs), reducing cell density, inducing cell dysfunction and accelerating cell aging. • Blue light overexposure leads to the imbalance of redox system and mitochondrial damage in CECs, causing senescence. • The antioxidant system of CECs is activated through the Keap1-Nrf2 signaling pathway. • Early Nrf2 pathway activation acts as a protective response against blue light-induced CEC damage.
Keywords:
LED blue light
corneal endothelial cells
oxidative stress
Keap1-Nrf2 signaling pathway
cellular senescence
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