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Ligustilide activates cGAS-STING to chemoprevent tobacco carcinogen-induced lung tumorigenesis

delete2026-06-20
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OA
AI
C
Caisheng Huang
Y
Yanni Tian
Y
Yonghu Chen
Y
Yijia Su
Q
Qiang Fu
X
Xianhua Che
Q
Qing Qian
Z
Zhe Jiang
X
Xuezheng Li *
DOI：10.1016/j.intimp.2026.117043delete
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Abstract

Abstract

En 中文
• First verified LIG directly binds STING with high affinity, and acts as a novel natural STING agonist. • LIG reverses NNK-induced cGAS-STING pathway suppression to exert lung cancer chemopreventive effects. • LIG triggers STING Golgi translocation and downstream signaling, uncovering natural product-mediated STING regulation.
Keywords:
Ligustilide
Lung Cancer
cGAS-STING pathway
Natural product

Journal

International Immunopharmacology cover
International Immunopharmacology
IF:
4.7
Papers:
1.6W
Citations:
4.1W

Organization

T
the affiliated hospital of yanbian university
Scholars:
17
Papers: 4
Citations: 0
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