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Limiting intestinal iron absorption rescues glial defects and extends lifespan in a Drosophila model of Friedreich's ataxia
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DOI：10.1016/j.nbd.2026.107550.png)
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Abstract
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• Iron accumulation in fh-GAAs frataxin-deficient flies is tissue-specific and predominantly affects the central nervous system. • Glial cells are preferential targets of frataxin deficiency, showing greater vulnerability than neurons in an iron-dependent manner. • Reducing intestinal iron uptake improves survival, locomotor function, brain morphology and glial integrity.
Keywords:
Friedreich Ataxia
Frataxin
Iron homeostasis
Glia
Gut-brain communication
Drosophila melanogaster
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