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Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis
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DOI：10.1016/j.stem.2026.05.013.png)
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Abstract
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• Pro-metastatic CRC organoid library is generated by serial transplantation • Pro-metastatic epigenetic changes converge on GATA6 loss • GATA6 loss promotes liver metastasis with minimal effects on primary tumors • GATA6 loss induces fetal-like and basal-like/squamous programs
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