Linking macro-scale structural–functional networks to micro-scale neurotransmitter architectures in first-episode, drug-naïve OCD

Zihan Li

doi:10.1016/j.pnpbp.2026.111733

Linking macro-scale structural–functional networks to micro-scale neurotransmitter architectures in first-episode, drug-naïve OCD

2026-05-07

0

PRE

AI

Z

Zihan Li

X

Xiaopan Zhang

J

Jin Sun

Y

Yuzhen Ding

Y

Yufei Shen

Y

Ya Tian

Y

Yifei Zhang

H

Huirong Guo

Y

Yarui Wei

S

Shaoqiang Han

Y

Yong Zhang

B

Baohong Wen *

DOI：10.1016/j.pnpbp.2026.111733

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Abstract

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• Our findings bridge macro-scale brain network abnormalities in OCD with the micro-scale spatial architecture of neurotransmitter systems. • Drug-naïve individuals with OCD show high coupling between macro-scale structural and functional network dysfunctions. • By linking the changes in GMV and ALFF components with neurotransmitter mapping, we propose a molecular susceptibility framework.

Keywords:

OCD

macro-scale brain networks

micro-scale neurotransmitter architecture

structural-functional coupling

drug-naïve patients

Linking macro-scale structural–functional networks to micro-scale neurotransmitter architectures in first-episode, drug-naïve OCD

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