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Linking phosphoinositide function to mitosis
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DOI：10.1016/j.celrep.2024.114273.png)
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Abstract
En 中文
Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes. Kinases and phosphatases can selectively modify the PtdIns composition of different cellular compartments, leading to the recruitment of specific binding proteins, which control cellular homeostasis and proliferation. Thus, while PtdIns affect cell growth and survival during interphase, they are also emerging as key drivers in multiple temporally defined membrane remodeling events of mitosis, like cell rounding, spindle orientation, cytokinesis, and abscission. In this review, we summarize and discuss what is known about PtdIns function during mitosis and how alterations in the production and removal of PtdIns can interfere with proper cell division.
Keywords:
PLECKSTRIN-HOMOLOGY-DOMAIN
HIGH-AFFINITY BINDING
CELL-SHAPE CHANGES
CLEAVAGE-FURROW
PLASMA-MEMBRANE
ESCRT-III
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE
MITOTIC SPINDLE
INTERCELLULAR BRIDGE
ACTIN CYTOSKELETON