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Lipidomic Profiling of Cutaneous Surface Lipid Alterations in Sensitive Scalp
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DOI：10.1016/j.chemphyslip.2025.105551.png)
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Abstract
En 中文
• Scalp sensitivity is an increasing global concern. While its pathophysiology remains unclear, evidence suggests its close association with skin barrier dysfunction caused by lipid secretion dysregulation. • Our study used a UPLC-QTOF-MS approach to reveals distinct differences in physical characteristics and surface lipid composition between sensitive and non-sensitive scalps, identifying specific lipids that play a critical role in scalp sensitivity. • Our study combined physiological parameter assessment (including pH, transepidermal water loss (TEWL), and erythema) and bioinformatics technology to investigate the lipid profile and underlying mechanisms of sensitive scalp. These results provide a theoretical basis for the development of more effective strategies for protecting scalp health and scientifically formulated scalp care products.
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