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Lipoprotein(a), remnant cholesterol, and high-sensitivity C-reactive protein as complementary biomarkers for myocardial infarction risk assessment
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DOI：10.1016/j.pcad.2026.04.011.png)
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Abstract
En 中文
• In a large primary prevention cohort (N = 306,183), lipoprotein(a), remnant cholesterol (RC), and high-sensitivity C-reactive protein (hsCRP) were each independently associated with incident myocardial infarction. • RC demonstrated the strongest association with MI risk among the three biomarkers. • MI risk increased stepwise with cumulative biomarker burden, with up to nearly threefold higher risk when all three biomarkers were elevated. • These associations persisted across key subgroups, including individuals with LDL-C < 100 mg/dL and those on statin therapy. • Combined assessment of these biomarkers modestly improved risk discrimination and reclassification beyond traditional clinical factors, supporting their complementary role in identifying residual MI risk.
Keywords:
Lipoprotein(a)
Remnant cholesterol
Inflammation
hsCRP
CVD
Myocardial infarction
UK Biobank
Lp(a)
Lipoprotein(a)
RC
Remnant cholesterol
hsCRP
High-sensitivity C-reactive protein
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