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Liquid biopsy - a narrative review with an update on current US governmental clinical trials targeting immunotherapy
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DOI：10.1080/20565623.2025.2527598.png)
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Abstract
En 中文
AimThis study aims to present a comprehensive international analysis of the existing techniques used in liquid biopsies and their use in isolating tumor markers to detect, predict, and monitor the results of cancer treatment.Materials and MethodsWe conducted a narrative review using a scoping review model based on three databases, including PubMed/Medline, Scopus, and Cochrane. The search criteria included all articles on liquid biopsy of the last five years (June 30th, 2023-Oct 30, 2024) ((liquid Biopsy) AND ((2023/06/30[Date - Publication]: 2024/10/30[Date - Publication]))). We also approached gray literature on this topic. We focused on review articles as an eligibility criterion for this narrative review, but we also carried out a United States registered clinical trials review targeting immunotherapy and liquid biopsy with the limitation recruiting and/or not yet recruiting (updated on March 31, 2025).ResultsWe screened 2645 articles from PubMed/Medline, Scopus, and Cochrane and 45 articles from the gray literature. We retrieved the full text for 325 articles. Liquid biopsies involve the extraction of tumor-derived components such as circulating tumor cells, circulating tumor DNA, and tumor extracellular vesicles from the bodily fluids of cancer patients. We found 25 United States registered governmental clinical trials targeting immunotherapy and liquid biopsy, of which 20 trials are recruiting and five trials are not yet recruiting.DiscussionDevelopments in medicine have led to a more comprehensive understanding of tumor features, including tumor load, tumor staging, heterogeneity, gene mutations, and clonal evolution. The utilization of liquid biopsies from cancer patients has provided novel opportunities for detection and ongoing monitoring, precision medicine-based therapy, and identification of markers for therapeutic resistance.
Keywords:
Liquid biopsy
cancer
circulating tumor cells
circulating tumor DNA
tumor extracellular vesicles
proteomics
RNA
precision medicine
Journal
F
IF:
2.1
Papers:
160
Citations:
0
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