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Liver X Receptor Agonists Enhances Intestinal Repair in Neonatal Piglets with Massive Bowel Resection
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DOI：10.1016/j.jlr.2026.101071.png)
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Abstract
En 中文
• Short bowel syndrome (SBS) represents the foremost cause of intestinal failure. • Neonates afflicted with SBS encounter formidable challenges and complications stemming from impaired intestinal adaptation. • Liver X receptor (LXR) agonist GW3965 improves intestinal adaptation in SBR piglets, suggesting LXR activation promising potential as a therapeutic strategy for children grappling with SBS.
Keywords:
short bowel syndrome
liver X receptors
intestinal adaption
regeneration
SBS
short bowel syndrome
PN
Parenteral nutrition
LXR
liver X receptor
NEC
necrotizing enterocolitis
SBR
small-bowel resection
EGFR
epidermal growth factor receptor
AREG
amphiregulin
EREG
epiregulin
TEM
transmission electron microscopy
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
IHC
immunohistochemistry
qRT - PCR
quantitative reverse transcription polymerase chain reaction
H&E
hematoxylin and eosin
WB
Western blotting
AB-PAS
Alcian blue-periodic acid Schiff
LPS
lipopolysaccharide
ABCG1
ATP Binding Cassette Subfamily G Member 1
APOB
Apolipoprotein B
GLUL
Glutamate-Ammonia Ligase
NFKB1
Nuclear Factor Kappa B Subunit 1
IL1B
Interleukin 1 Beta
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