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Long non-coding RNA MIAT Functions as a ceRNA to Protect Uveal Melanoma from Oxidative Stress by Sponging miR-4306 and Upregulating CXCR4
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DOI：10.1016/j.exer.2026.111043.png)
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Abstract
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• Identification of a novel ceRNA axis: LncRNA MIAT acts as a molecular sponge for miR-4306, leading to upregulation of CXCR4, which protects uveal melanoma (UVM) cells from oxidative stress and apoptosis. • Functional validation in UVM cells: Overexpression of lncRNA MIAT alleviates H2O2-induced oxidative damage and apoptosis, while miR-4306 exerts tumor-suppressive effects. • Prognostic risk model: A six-gene oxidative stress-related signature effectively stratifies UVM patients into high- and low-risk groups with distinct survival and immune infiltration profiles. • Therapeutic implications: The MIAT/miR-4306/CXCR4 axis represents a promising therapeutic target, and the risk model may serve as a prognostic tool for UVM management.
Keywords:
LncRNA MIAT
miR-4306
CXCR4
oxidative stress
uveal melanoma
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