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Long-term clonal analysis using stochastic models reveals heterogeneity and quiescence of hematopoietic stem cells
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DOI：10.1016/j.compbiomed.2026.111650.png)
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Abstract
En 中文
• Clonal data offers a robust approach to explore hematopoietic stem cell dynamics. • Homogeneous HSC population cannot reproduce observed long-term clonal patterns. • Niche-mediated quiescence improves model fit across different clonality metrics. • Model results suggest reversible transition between HSC quiescence and activation.
Keywords:
Hematopoietic stem cells
Quiescence
Clonal tracking
Stochastic modeling
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