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Long term functional outcomes and health-related quality of life in patients with esophageal atresia - A tertiary centre experience
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DOI：10.1016/j.jpedsurg.2025.162698.png)
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Abstract
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Purpose: This study evaluates the clinical outcomes and compares the quality of life in esophageal atresia patients over the past two decades. Method: Medical records of all esophageal atresia (EA) patients who received surgical repair between 1997 and 2022 in a tertiary center were reviewed to assess for associated anomalies and complications. Both patients and parents were invited to participate in health-related quality of life (HRQOL) studies either in person, via phone or online. The Pediatric Quality of Life Inventory Generic (Peds-QL) Core Scale Version 4.0 and Gastrointestinal Quality of Life Index (GIQLI) were used as generic and system-specific assessment tools respectively. Numeric values were expressed in medians (interquartile range). Results: A total of 31 patients were eligible for the study. The median birth weight was 2.47 kg (1.93 -3.08). The smallest patient had a birth weight of 1.36 kg. Primary repair was performed in 28 (90.3 %) patients. Anastomotic leak was reported in two (6.45 %) patients, both of them requiring revision surgery. Repeated endoscopic dilatation was required in 11 (35.5 %) patients and seven (22.6 %) required anti-reflux procedures. For the HRQOL assessment, our cohort of patients showed an overall score of 76.1 (62-93.5), physical score of 90.6 (68.8-10 0) and psychosocial score of 63.3 (56.7-91.7) when using the generic Peds-QL questionnaire. When using the system-specific GIQLI, they scored 120 (106.8-128). EA patients show significantly poor HRQOL as reflected in both generic and system-specific questionnaires. Conclusion: Long term survivors of esophageal atresia demonstrated inferior HRQOL compared to normal population in both generic and system-specific assessment tools. Life-long follow-up and monitoring are essential in order to provide holistic care to these patients. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Keywords:
Esophageal atresia
Esophageal atresia with tracheoesophageal
fistula
Quality of life
Health-related quality of life
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