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Longitudinal changes in the antibody responses and adverse reactions across successive SARS-CoV-2 mRNA vaccinations from the primary series to the JN.1-adapted booster in hospital employees: A 4-year prospective cohort study
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DOI：10.1016/j.vaccine.2026.128887.png)
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Abstract
En 中文
• Anti–receptor-binding domain IgG titers and adverse reactions to vaccination were investigated across successive boosters. • XBB.1.5 and JN.1 boosters raised target-strain IgG more than wild-type (WT) IgG. • The XBB.1.5/WT IgG ratio, reflecting variant-specific responses, remained elevated up to 350 days post-XBB.1.5 booster. • Local reaction frequency and severity remained stable across doses, whereas those of systemic reactions declined. • Fever was associated with higher IgG titers at several, but not all, vaccination time points.
Keywords:
SARS-CoV-2
mRNA vaccine
Reactogenicity
Antibody response
Adverse reactions
Post-vaccination fever
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