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Loss of caveolar A1 adenosine receptor signalling blunts anti-adrenergic control in heart failure

delete2026-06-24
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OA
AI
M
Marta Mazzola, PhD
H
Houcheng Wang, MRes
D
Di Lang, PhD
M
Marina Balycheva, MD, PhD
N
Navneet Bhogal, BSc
J
Jose L Sanchez-Alonso, PhD
I
Ivan Diakonov, PhD
C
Carla Lucarelli, MD, PhD
E
En-Chi Lai, BSc
P
Prakash P Punjabi, MS, MCh
M
Michele Miragoli, PhD
G
Giuseppe Faggian, MD
A
Alexey V Glukhov, PhD *
J
Julia Gorelik, PhD *
DOI：10.1093/cvr/cvag131delete
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Abstract

Abstract

En 中文
Adenosine, acting through A1 adenosine receptors (A1ARs), exerts anti-adrenergic effects by inhibiting β1-adrenergic receptor (β1AR)–mediated cAMP production and contractility in the heart. While the functional interaction between A1ARs and β1ARs is well established in both atrial and ventricular myocytes, the subcellular compartmentalisation of this crosstalk and how it is disrupted in heart failure (HF) remains incompletely understood. This study investigates the spatial confinement of A1AR–β1AR signalling within atrial microdomains and assesses how structural remodelling in HF alters this regulatory axis.

Journal

Cardiovascular Research cover
Cardiovascular Research
IF:
13.3
Papers:
1.2W
Citations:
2.8W

Organization

I
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