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Loss of phospholamban phosphorylation blunts Ca2+ handling during the cellular adrenergic response
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DOI：10.1016/j.yjmcc.2026.05.001.png)
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Abstract
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• Mass spectrometry shows no phosphorylation of phospholamban (PLB) in PLB-DM mice. • PLB-DM mice do not show remodeling to compensate for loss of PLB phosphorylation. • In-depth analysis of Ca2+ handling uncovers role of PLB phosphorylation in the heart. • Loss of PLB phosphorylation lowers SR Ca2+ load and release. • PLB-DM myocytes show blunted adrenergic response with slow Ca2+ reuptake kinetics.
Keywords:
Calcium signaling
Phospholamban
Sarcoplasmic reticulum
Excitation-contraction coupling
Adrenergic response
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