Loss of Snord115 mitigates Snord116-driven sleep abnormalities in mouse models of Prader-Willi syndrome

Julie C. Rivière

doi:10.1016/j.nbd.2026.107551

Loss of Snord115 mitigates Snord116-driven sleep abnormalities in mouse models of Prader-Willi syndrome

2026-07-30

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J

Julie C. Rivière *

V

Virginie Marty

J

Jérôme Cavaillé *

L

Laure Verret *

DOI：10.1016/j.nbd.2026.107551

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• Snord116 deletion disrupts sleep architecture in mice. • Snord115 loss suppresses Snord116-dependent REM sleep abnormalities. • REM sleep changes occur independently of MCH neuron decrease. • Hypothalamic transcriptomic changes are limited across genotypes.

Keywords:

snoRNA

SNORD116

SNORD115

Prader-Willi syndrome

REM sleep

Hypocretin

MCH

Loss of Snord115 mitigates Snord116-driven sleep abnormalities in mouse models of Prader-Willi syndrome

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