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Lossy Source Coding With DNA Base Composition Constraints
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DOI：10.1109/tcomm.2026.3704248.png)
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Abstract
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Deoxyribonucleic acid (DNA) data storage is recognized as a transformative archival technology due to its ultrahigh density and exceptional longevity. However, its practical capacity is severely limited by the conventional separated architecture, where lossy source coding and DNA constraint satisfaction are implemented as independent, sequential stages. This work proposes a unified framework that integrates lossy compression with DNA base composition constraints. A protograph-based low-density parity-check code structure is employed for efficient quantization. To enable joint optimization, a novel multi-point central difference method is devised to approximate gradients through non-differentiable operations. Experimental results demonstrate that the proposed system directly generates biochemically feasible DNA sequences while approaching the rate-distortion bound. This will advance the integration of information theory with physics-dependent system design.
Keywords:
Lossy source coding
P-LDPC codes
DNA base composition
rate-distortion performance
biological composition constraint
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8.3
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1.2W
Citations:
3.6W
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NATURE COMMUNICATIONS
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